The E2F transcription factor 2: What do we know?
نویسندگان
چکیده
E2F transcription factor 2 (E2F2) is a member of the family factors. The classical view that some E2Fs act as "activators" and others "inhibitors" cell cycle gene expression. However, so-called "activator" E2F2 particularly enigmatic, with seemingly contradictory roles in cycle, proliferation, apoptosis, inflammation, migration invasion. How can we rationalize apparently opposing functions different situations? This difficult because methods studying have yielded conflicting results, so extrapolating mechanisms from an observed endpoint challenging. review will attempt to summarize clarify these issues. focuses on genetic studies helped elucidate biological enhanced our understanding how integrated into pathways controlling also discuss function cancer other diseases. provides strong basis for further research clinical potential E2F2.
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ژورنال
عنوان ژورنال: BioScience Trends
سال: 2021
ISSN: ['1881-7815', '1881-7823']
DOI: https://doi.org/10.5582/bst.2021.01072